Course Syllabus for "CHEM201: Advanced Organic Chemistry"
Remember that organic chemistry is the discipline that studies the properties and reactions of organic, carbon-based compounds. This course is intended to be taken after the first two semesters of organic chemistry. Many of the topics within this outline have been covered in the first two semesters of organic chemistry; however, this course will explore these topics in much greater depth. It is important to make sure that you have a good grasp of the concepts from earlier organic chemistry courses before moving on to this course. We begin by studying a unit on ylides, benzyne, and free radicals. Many free radicals affect life processes. For example, oxygen-derived radicals may be overproduced in cells, such as white blood cells that try to defend against infection in a living organism. In the first unit, you will learn about free radicals, including oxygen-containing compounds. Afterward we move into a comprehensive examination of stereochemistry, as well as the kinetics of substitution and elimination reactions. After learning the information in that unit, you will be able to describe reaction mechanisms. The course wraps up with a final unit, which is a survey of various hetereocyclic structures, including their MO theory, aromaticity, and reactivity.
Upon successful completion of this course, you will be able to:
- Describe free radicals in terms of stability, kinetics, and bond dissociation energies.
- Describe the stereochemistry and orbitals involved in photochemical reactions.
- Describe enantiomers, diastereomers, pro-S and pro-R hydrogens, and Re/Si faces of carbonyls.
- Perform conformational analysis of alkanes and cyclohexanes.
- Describe reaction mechanisms in terms of variousparameters (i.e.,kinetics, Curtin-Hammet principle, Hammond postulate,etc.).
- Describe the chemistry of the heterocycles listed in Unit 3in terms of molecular orbital theory, aromaticity, and reactions.
In order to take this course, you must:
√ Have access to a computer.
√ Have a basic understanding of computers.
√ Have continuous broadband Internet access.
√ Have the ability/permission to install plug-ins or software (e.g., Adobe Reader or Flash).
√ Have the ability to download and save files and documents to a computer.
√ Have the ability to open Microsoft files and documents (.doc, .ppt, .xls, etc.).
√ Be competent in the English language.
√ Have read the Saylor Student Handbook.
Welcome to CHEM 201. Below, please find general information on this course and its requirements.
Course Designer: Rachel Lerebours
Primary Resources: This course is composed of a range of free online materials. However, the course primarily makes use of the following materials:
- University of Calgary: Professor Ian Hunt’s “Organic Chemistry”
- Michigan State University: Professor William Reusch’s “Virtual Textbook of Organic Chemistry”
- Metropolitan State College of Denver: Professor Milton Weider’s “Advanced Organic Chemistry”
Requirements for Completion: In order to complete this course, you will need to work through each unit and all of its assigned materials. You will also need to complete the Final Exam. In order to “pass” this course, you will need to earn a 70% or higher on the FinalExam. Your score on the exam will be tabulated as soon as you complete it. If you do not pass the exam, you may take it again.
Time Commitment: This course should take you a total of 60 hours to complete. Each unit includes a “time advisory” that lists the amount of time you are expected to spend on each subunit. These should help you plan your time accordingly. Please look at the time advisories prior to starting the course to determine how much time you have over the next few weeks to complete eachunit.
Tips/Suggestions: This is a very difficult course, so allow time to “digest” the material. When needed, review relevant information from the prerequisite courses. Take plenty of notes and review daily.