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BIO407: Immunology

Unit 8: Regulation of Immune Response   This last unit will cover the major methods that scientists and researchers use to manipulate the immune system in our favor, including vaccination (to boost immune responses) and immunosuppression (to temper immune responses to allergens or transplantations).  We will also discuss the development of new treatments that promise to direct our immune system to recognize and attack tumor cells.

Unit 8 Time Advisory
This unit will take you 6 hours to complete. ☐    Unit 8 Introduction

☐    Subunits 8.1 - 8.2: 1 hour

☐    Subunit 8.3: 2 hours

☐    Subunit 8.4: 2.5 hours

☐    Unit 8 Assessment: 0.5 hours

Unit8 Learning Outcomes
Upon successful completion of this unit, students will be able to:

  • Demonstrate an understanding of the ways in which medical professionals use their understanding of the immune system to help fight disease.
  • Distinguish between those means that involve immunosuppression and those that involve a boosting of the immune system.
  • Explain how and why various cells/molecules of the immune system can be used to combat cancers.

8.1 Immunosuppression   - Reading: National Institutes of Health: Professor Charles Janeway et al.’s Immunobiology: “Extrinsic regulation of unwanted immune responses” Link: National Institutes of Health: Professor Charles Janeway et al.’s Immunobiology: “Extrinsic Regulation of Unwanted Immune Responses” (HTML)
 
Instructions: Read this page in its entirety along with all associated figures.  This will cover the material in 8.1-8.2.
 
This resource will take approximately 1 hour to complete.

 Terms of Use: Please respect the copyright and terms of use
displayed on the webpage above.

8.1.1 Corticosteroids   Note: This subunit is covered by the reading for subunit 8.1.

8.1.2 Cytotoxic Drugs   Note: This subunit is covered by the reading for subunit 8.1.

8.1.3 T-cell Intereference Drugs   Note: This subunit is covered by the reading for subunit 8.1.

8.2 Biological Therapy   Note: This subunit is covered by the reading for subunit 8.1.

8.3 Cancer Treatment   - Reading: National Institutes of Health: Professor Charles Janeway et al.’s Immunobiology: “Using the Immune Response to Attack Tumors” Link: National Institutes of Health: Professor Charles Janeway et al.’s Immunobiology: “Using the Immune Response to Attack Tumors” (HTML)
 
Instructions: Read this page in its entirety along with all associated figures. 
 
This resource will take approximately 1 hour to complete.

 Terms of Use: Please respect the copyright and terms of use
displayed on the webpage above.
  • Lecture: The University of South Carolina School of Medicine: Dr. Mitzi Nagarkatti’s “Tumor Immunology I and II” Link: The University of South Carolina School of Medicine: Dr. Mitzi Nagarkatti’s “Tumor Immunology I and II” (Adobe Flash, MP3 or Quicktime)  

    Instructions: In the Immunology folder, click on the “Tumor Immunology” lectures.  You have the choice of listening to these on your computer with audio (Tumor Immunology I) listening and watching (Tumor Immunology II) or downloading the lectures to an MP3 player.  This will cover the material in 8.4.  Please note that the first lecture has no slideshow and is available in MP3 only.  Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.

    These resources should take approximately 1 hour to complete.

8.3.1 Tumor Rejection Antigens   Note: This subunit is covered by the reading for subunit 8.3.

8.3.2 Monoclonal Antibodies   Note: This subunit is covered by the reading for subunit 8.3.

8.3.3 Immunogenicity of Tumors   Note: This subunit is covered by the reading for subunit 8.3.

8.4 Vaccination   - Reading: National Institutes of Health: Professor Charles Janeway et al.’s Immunobiology: “Manipulating the Immune System to Fight Infection” Link: National Institutes of Health: Professor Charles Janeway et al.’s Immunobiology: “Manipulating the Immune System to Fight Infection” (HTML)
 
Instructions: Read this page in its entirety along with all associated figures.
 
This resource will take 75 minutes to complete.

 Terms of Use: Please respect the copyright and terms of use
displayed on the webpage above.
  • Reading: University of California, Irvine, College of Medicine’s “Chapter 22: Vaccination” Link: University of California, Irvine, College of Medicine’s "Chapter 22: Vaccination" (PDF)

    Instructions: Click the link above, and scroll down to Chapter 22 to download the pdf file. Read the text and answer the questions at the end of the chapter.

    This resource will take approximately 30 minutes to complete.

    Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.

  • Reading: Virology: Dr. Vincent Racaniello’s “Vaccine Lectures” Link: Virology: Dr. Vincent Racaniello’s “Vaccine Lectures” (PDF)

    Instructions: Click on and watch either the 67 MB movie or the 247 MB movie. The 247 MB movie is clearer. 

    This resource will take 75 minutes to complete. 

    Terms of Use: Please respect the copyright and terms of use displayed on the webpage above. 

8.4.1 Attenuated Organisms   Note: This subunit is covered by the reading for subunit 8.4.

8.4.2 Whole cell and acellular or sub-unit vaccines   Note: This subunit is covered by the reading for subunit 8.4.

8.4.3 Conjugate Vaccines   Note: This subunit is covered by the reading for subunit 8.4.

8.4.4 Adjuvants   Note: This subunit is covered by the reading for subunit 8.4.

8.4.5 Live-Attenuated Vaccines   Note: This subunit is covered by the reading for subunit 8.4.

8.4.6 Routes of Vaccines   Note: This subunit is covered by the reading for subunit 8.4.

Unit 8 Assessment   - Reading: The Saylor Foundation's "BIO407 Unit 8 Quiz" Link: The Saylor Foundation's "BIO407 Unit 8 Quiz" (PDF)

 Instructions: Please take the quiz. When you have finished, check
your work against the "[BIO407 Unit 8 Quiz Answer
Key](http://www.saylor.org/site/wp-content/uploads/2012/11/BIO407-Unit-8-Quiz-Answer-Key-FINAL.pdf)."
(PDF)  

 The assessment will take approximately 30 minutes to complete.