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BIO405: Computational Biology

Unit 4: Current Topics in Computational Biology   *In this final unit, we will shift our focus from theoretical generalities in computational procedure to specific applications of Computational Biology in current research.   This unit should provide you with a better understanding of the ways in which Computational Biology can applied in research.  We will look at topics in Computational Biology that have come up in the mainstream media and study papers that have recently been published in scientific journals.

Note: The content of this unit will change over time and is dependent on the contents of the current issue of the journal, or current topics in the news.   This unit will likely be more of an overview than an in-depth study; it should expose you to various research methods and approaches to drawing conclusions from data. *

Unit 4 Time Advisory
This unit will take approximately 12 hours to complete.

☐    Subunit 4.1.1: 6 hours

☐    Subunit 4.1.2: 6 hours

Unit4 Learning Outcomes
Upon completion of this unit, students will be able to: - Provide specific examples of how computational biology is currently being used. - Identify resources for information on computational biology.

4.1 Current Research   4.1.1 In the News   4.1.1.1 Molecular Biology   - Reading: ScienceDaily News’ “Molecular Biology Articles” Link: ScienceDaily News’ “Molecular Biology Articles” (HTML)

 Instructions: At this page, click on the ‘Articles’ tab and then
click on the molecular biology link.  Try using either the search
option to look for articles related to what you have covered in
other units or take a different approach and look for articles that
give you a sense of what recent discoveries have taken place within
areas you have covered in the course.  

 Studying these materials should take approximately 3 hours.  

 Terms of Use: Please respect the copyright and terms of use
displayed on the webpage above.

4.1.1.2 Biological Processes   - Reading: e! Science News’ “Fundamental Biological Processes” Link: e! Science News’ “Fundamental Biological Processes” (HTML)

 Instructions: This site allows you to choose from a variety of
articles related to biological processes.  Search under
Computational Biology to locate articles related to material in the
course.  This could simply be an opportunity to late articles that
cover an area of personal interest within computational biology.  

 Studying these materials should take approximately 3 hours.  

 Terms of Use: Please respect the copyright and terms of use
displayed on the webpage above.

4.1.2 In Scientific Journals   4.1.2.1 Molecular Biology   - Reading: “Algorithms for Molecular Biology,” “PLOS Computational Biology,” and “BMC Molecular Biology” Link: “Algorithms for Molecular Biology”, “PLOS Computational Biology”, and “BMC Molecular Biology” (HTML)

 Instructions: These websites offer open access articles relating to
molecular and computational biology.  Try either using the Search
option to look for articles related to what you have covered in
other units (such as phylogenetic reconstruction or hidden Markov
models) or take a different approach and look for articles that give
you a sense of what recent discoveries have taken place within areas
you have covered in the course.  

 Studying these materials should take approximately 3 hours.  

 Terms of Use: Please respect the copyright and terms of use
displayed on the webpage above.

4.1.2.2 Biological Processes   - Reading: FreePatentsOnline.com: Ravie Chandren Muniyandi and Abdullah Mohammad Zin’s “Modeling biological processes using membrane computing formalism” Link: FreePatentsOnline.com: Ravie Chandren Muniyandi and Abdullah Mohammad Zin’s “Modeling biological processes using membrane computing formalism” (HTML)

 Instructions: The article discusses how processes are analyzed and
how membrane computing is used to define models of specific cellular
systems.  

 Reading this material should take approximately 3 hours.  

 Terms of Use: Please respect the copyright and terms of use
displayed on the webpage above.