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BIO403: Biotechnology

Unit 1: Introduction to Biotechnology   In this unit, you will analyze DNA structure, practice Mendelian genetics problems, and familiarize yourself with gene expression studies and with biological systems in biotechnology.

Unit 1 Time Advisory
This unit should take you approximately 2.5 hours to complete.

☐    Subunit 1.1: 0.5 hour

☐    Subunit 1.2: 1.0 hour

☐    Subunit 1.3: 1.0hour

Unit1 Learning Outcomes
Upon successful completion of this unit, the student will be able to:

  • Analyze the structure of a DNA double helix based on an X-ray diffraction pattern.
  • Calculate the genotype and phenotype of offspring using a Punnett square.
  • Describe the scope of biotechnology.

1.1 DNA Structure   - Reading: PBS: Lexi Krock's “Anatomy of Photo 51” Link: PBS: Lexi Krock's “Anatomy of Photo 51” (HTML)
 
Instructions: Please investigate the critical evidence that led to the model of the DNA double helix.  Rosalind Franklin’s X-ray diffraction image #51 is shown here.  Click on the “Launch interactive” button and advance step by step from image #51 to the double helix model of DNA.  Please note that all structural parameters of the double helix are provided by image #51.
 
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1.2 Mendelian Inheritance   - Web Media: Khanacademy’s “Introduction to Heredity” Link: Khanacademy’s “Introduction to Heredity” (Adobe Flash)
 
Also available in:

[YouTube](http://www.youtube.com/watch?v=eEUvRrhmcxM&feature=player_embedded)  
    
 Instructions: Please watch the video (18 minutes) for a
step-by-step tutorial on using Punnett squares to determine how
alleles of one gene segregate.  
    
 Terms of Use: Please respect the copyright and terms of use
displayed on the webpage above.
  • Web Media: Khanacademy’s “Punnett Square Fun” Link: Khanacademy’s “Punnett Square Fun” (Adobe Flash)
     
    Also available in:

    YouTube
     
    Instructions: Please watch the video (26 minutes) for a step-by-step tutorial on using Punnett squares to determine how alleles of more than one gene assort independently.  During sexual reproduction, both parents pass on some of their traits to their offspring(s).  Mendel's law of segregation describes how different versions of one trait are combined in the offspring.  Mendel's law of independent assortment describes how different versions of different traits are combined in the offspring.  Please make sure that you can predict the genotype and phenotype of the F1 generation using Punnett squares.  You may need to follow this video several times.  Be patient; it may take some time to get used to the Punnett squares.  This is a great tool, used every day in genetic counseling.
     
    Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.

  • Assessment: The Saylor Foundation: "BIO403 Unit 1.2 Assessments" Link: The Saylor Foundation: "BIO403 Unit 1.2 Assessments" (HTML)
     
    Instructions: You will find links to the following three assessments on this page: “Mendelian Inheritance of Traits,” “Codominance – an Extension of the Mendelian Inheritance of Traits,” and “Independent Assortment – Dihybrid Cross.” These are multiple choice assessments with one correct answer. Clicking on an answer will bring you to another page. If your answer is correct, then it is acknowledged with a short explanation. Please read the explanation carefully and proceed to the next assessment as prompted at the bottom of the page. If you clicked on the wrong answer, then the click will bring you to a tutorial page. Please study the tutorial page carefully. At the end of the tutorial page, you will be prompted to return to the assessment and complete it again. You can also move between multiple choice pages using the links at the top of the page. Please complete the three assessments in order, because the assessments are listed in increasing complexity.   
     

1.3 Biotechnology Fields   - Reading: Access Excellence: Pamela Peters' “What Is Biotechnology?” Link: Access Excellence: Pamela Peters' “What Is Biotechnology?” (HTML)
 
Instructions: Please read this page carefully.  When you finish it, please continue your reading: Open the “Where Did Biotechnology Begin?” link at the bottom of the page. Please note that making bread, cheese, beer, or wine are all historical biotechnology applications.
 
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  • Reading: All About Biotechnology's “Traditional Biotechnology vs. New Biotechnology” Link: All About Biotechnology's “Traditional Biotechnology vs. New Biotechnology” (HTML)
     
    Instructions: Please read this page to get a basic overview on the differences between traditional and modern biotechnology application.  Please note that modern biotechnology is able to genetically engineer living organisms, and it often does so.
     
    Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.