Loading...

BIO402: Pathobiology

Unit 4: Diseases of the Immune System   Diseases of the immune system are typically caused by immune systems that are either too active or not active enough.  Diseases that can result from an underactive immune system include AIDS (Autoimmune Deficiency Syndrome) and SCID (Severe Combined Immunodeficiency Syndrome).  An overactive immune system can cause allergies and asthma, as well as autoimmune disorders such as Lupus and Insulin Dependent Diabetes Mellitus.  This unit focuses on these prototype diseases, although there are thousands of disease states that can impact the immune system.

Unit 4 Time Advisory
This unit will take approximately 12 hours to complete.

☐    Subunit 4.1.1: 3 hours

☐    Subunit 4.1.2: 3 hours

☐    Subunit 4.2.1: 3 hours

☐    Subunit 4.2.2: 3 hours

Unit4 Learning Outcomes
Upon successful completion of this unit, the student will be able to:

  • Describe how HIV develops into AIDS and the treatment options for this disease.
  • Compare and contrast diseases involving an overactive and underactive immune system, including SCID, HIV, allergies, and asthma as examples.
  • Explain how an autoimmune response leads to diseases such as Type 1 Diabetes Mellitus and Lupus (SLE).

4.1 Immune System Disease Caused by an Underactive Immune System   4.1.1 HIV/AIDS   - Reading: Centers for Disease Control and Prevention’s “Basic Information about HIV and AIDS” Link:  Centers for Disease Control and Prevention’s “Basic Information about HIV and AIDS” (HTML)
 
Instructions:  This reading will provide you with some background information on HIV/AIDS.
 
Terms of Use:  Please respect the copyright and terms of use displayed on the webpage above.

  • Web Media: Discovery Health’s “HIV/AIDS” Link: Discovery Health’s “HIV/AIDS” (Adobe Flash)
      
    Instructions: Discovery Health offers an in-depth video series about HIV/AIDS.  Watch HIV/AIDS Part 1, Part 2, Part 3, and Part 4 to get a complete understanding of this disease, its signs and symptoms, it treatments, and its pertinent research advancements.  Be sure to take notes and stop the audio as needed.
     
    Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.

4.1.2 SCID   - Reading: SCID.net’s “Missing Body Defense Systems” Link:  SCID.net’s Missing Body Defense Systems (HTML)
 
Instructions:  This web page introduces the disease known as SCID, discussing its underlying causes as well as its principal treatments (including gene therapy).
 
Terms of Use:  Please respect the copyright and terms of use displayed on the webpage above.

  • Lecture: You Tube: Rebecca Proctor, Chiquetta Silver, and Shamonia Wright’s “Biotechnology and Gene Therapy” Link: Rebecca Proctor, Chiquetta Silver, and Shamonia Wright’s “Biotechnology and Gene Therapy“ (YouTube)
     
    Instructions:  This video (10:01 minutes) discusses gene therapy, which has been successful in treating children with SCID, as well as a number of other disease states.  Though gene therapy has not yet been fully researched, it can drastically increase a patient’s quality of life. 
     
    Terms of Use:  Please respect the copyright and terms of use displayed on the webpage above.

4.2 Immune System Disease Caused by an Overactive Immune System   4.2.1 Allergies and Asthma   - Web Media: You Tube: “Allergy 3D Medical Animation” Link: “Allergy 3D Medical Animation“ (YouTube)
 
Instructions:  Watch this video (1:27 minutes) to learn about the development of allergies.
 
Terms of Use:  Please respect the copyright and terms of use displayed on the webpage above.

  • Reading: Mercks Manuals Online Medical Library’s “Asthma” Link:  Mercks Manuals Online Medical Library’s “Asthma” (HTML)
     
    Instructions:  Read about asthma and its causes and treatments.  You will find three short videos to watch as you read through the material; please view them in order to reinforce what you have read.
     
    Terms of Use:  Please respect the copyright and terms of use displayed on the webpage above.

4.2.2 Autoimmune Disorders   4.2.2.1 Systemic Lupus Erythematosus (SLE)   - Web Media: Lupus Foundation of America’s “Target Awareness: What is Lupus?” Link: Lupus Foundation of America’s “Target Awareness: What is Lupus?” (Adobe Flash)
 
Also available in:

[YouTube](http://www.youtube.com/watch?v=hIabco_hl9c&feature=player_embedded)  
    
 Instructions:  Watch this short video (5:55 minutes) about the
causes and symptoms of lupus.  
    
 Terms of Use:  Please respect the copyright and terms of use
displayed on the webpage above.

4.2.2.2 Insulin Dependent Diabetes Mellitus   - Web Media: Clearly Health’s “What is Type 1 Diabetes?” Link: Clearly Health’s “What is Type 1 Diabetes“ (YouTube)
 
Also available in:
Adobe Flash
 
Instructions:  Watch this video (2:15 minutes) to learn about insulin dependent diabetes mellitus (IDDM).  One suggested cause of this disease is autoimmunity, where the body attacks its own cells. 
 
Terms of Use:  Please respect the copyright and terms of use displayed on the webpage above.

  • Reading: PubMed Central: W. Rodger’s “Insulin-Dependent (Type I) Diabetes Mellitus” Link: PubMed Central: W. Rodger’s “Insulin-Dependent (Type I) Diabetes Mellitus” (PDF)
     
    Instructions: Scroll down and click on the complete article to read this 11-page review about Insulin-Dependent Diabetes Mellitus. 
     
    Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.

  • Assessment: The Saylor Foundation’s “Underactive, Overactive, and Autoimmune Disorders” Link: The Saylor Foundation’s “Underactive, Overactive, and Autoimmune Disorders” (HTML)

    Instructions: Complete this assessment. Match the key terms with their corresponding definition.

    Completing this assessment should take approximately 20 minutes.