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BIO402: Pathobiology

Unit 3: Losing the Battle—Infectious Disease, Cell Injury and Death, and Neoplasia   In this unit, you will learn what happens when the immune system is challenged.  We will discuss infectious diseases and examine cell injury and death. Infectious disease can be caused by numerous different microorganisms, including viruses, bacteria, fungi, protozoa, and even parasitic worms, among other agents.  They are typically spread from direct contact via person to person or may be carried through insect vectors such as mosquitoes or ticks or even in food or the environment.  To learn more about specific organisms, you may want to take BIO307: Microbiology.

We will also look at what happens when cells die, both normally and abnormally.  These death processes are referred to as programmed cell death or apoptosis or death as a result of injury or disease, known as necrosis.  Finally, we will see what happens when cells no longer heed their growth checkpoints and grow uncontrollably.  You likely know of this as cancer.  

Unit 3 Time Advisory
This unit will take approximately 9 hours to complete.

☐    Subunit 3.1: 3 hour

☐    Subunit 3.2: 3 hours

☐    Subunit 3.3: 3 hours

Unit3 Learning Outcomes
Upon successful completion of this unit, the student will be able to:

  • Define the term infectious disease, giving examples of causative agents and resulting disease states
  • Differentiate between apoptosis and necrosis.
  • Describe how normal cells become immortalized to become cancer cells.

3.1 Introduction to Infectious Diseases   - Lecture: BioEd’s Online Presentation: Dr. Christine Herrmann’s “Introduction to Infectious Diseases” Link:  BioEd’s Online Presentation: Dr. Christine Herrmann’s “Introduction to Infectious Diseases” (Adobe Flash)
 
Instructions:  Click on “Introduction to Infectious Diseases” and view the lecture (16:54 minutes).  Make sure to take notes, stopping the audio as needed.
 
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3.2 Cell Injury and Death   - Reading: Queen’s University of Belfast: Staff Workstation Initiative 3’s “Cell Injury and Cell Death” The Saylor Foundation does not yet have materials for this portion of the course. If you are interested in contributing your content to fill this gap or aware of a resource that could be used here, please submit it here.

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3.3 Neoplasia   - Web Media: Cold Spring Harbor Laboratory’s “Inside Cancer” Link: Cold Spring Harbor Laboratory’s “Inside Cancer” (Adobe Flash)
 
Instructions: Click on “Hallmarks of Cancer.”  Work your way through the eight tabs to the left, starting with “Overview.”  Each of these tabs has several pages.  Make sure to view each of these pages.  If you enjoy this material, consider taking BIO404: Cancer Biology.
 
Terms of Use:  Please respect the copyright and terms of use displayed on the webpage above.

  • Assessment: The Saylor Foundation’s “Disease, Cell Injury and Death, and Cancer” Link:  The Saylor Foundation’s “Disease, Cell Injury and Death, and Cancer” (HTML)
     
    Instructions: Complete the multiple choice assessment above. 

    Completing this assessment should take approximately 25 minutes.